Voss Lab


Voss SR, Murrugarra D, Jensen TB, Monaghan JR. 2017. Transcriptional correlates of proximal-distal identify and regeneration timing in axolotl limbs. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. Link to article


Woodcock MR, Vaughn-Wolfe J, Elias A, Kump DK, Kendall KD, Timoshevskaya N, Timoshevskiy V, Perry DW, Smith JJ, Spiewak JE, Parichy DM & Voss SR. 2017. Identification of Mutant Genes and Introgressed Tiger Salamander DNA in the Laboratory Axolotl, Ambystoma mexicanum. Scientific Reports. Link to article


Keinath MC, Voss SR, Tsonis PA, Smith JJ. 2016. A linkage map for the Newt Notophthalmus viridescens: Insights in vertebrate genome and chromosome evolution. Developmental Biology. PubMed


Keinath MC, Timoshevskiy VA, Tsonis PA, Voss SR, Smith JJ. 2015. Characterization of the large genome of the salamander Ambystoma mexicanum using shotgun and laser capture chromosome sequencing. Scientific Reports. PubMed


McCusker CD, Athippozhy A, Diaz-Castillo C, Fowlkes C, Gardiner DM, Voss SR. 2015. Positional Plasticity in Regenerating Amybstoma mexicanum Limbs Is Associated With Cell Proliferation and Pathways of Cellular Differentiation. BMC Developmental Biology. PubMed


Voss SR, Woodcock MR, Zambrano L. 2015. Tale of two axolotls. Bioscience. Link to article


Voss SR, Palumbo A, Nagarajan R, Gardiner DM, Muneoka K, Stromberg AJ, Ahtippozhy AT. 2015. Gene expression during the first 28 days of axolotl limb regeneration I: Experimental design and global analysis of gene expression. Regeneration. Link to article


Ponomareva LV, Athippozhy AT, Thorson JS, Voss SR. 2015. Using Ambystoma mexicanum (Mexican Axolotl) embryos, chemical genetics, and microarray analysis to identify signaling pathways associated with tissue regeneration. In press, Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology. PubMed


Sousounis K, Athipozzhy AT, Voss SR, Tsonis PA. 2014. Plasticity for axolotl lens regeneration is associated with age-related cellular differentiation of iris and ontogeny of the immune system. Regeneration 1:47-57. Link to article


Thompson S, Muzinic L, Muzinic C, Niemiller ML, Voss SR. 2014. Probability of Regenerating a Normal Limb After Bite Injury in the Mexican Axolotl (Ambystoma mexicanum). Regeneration 1:27-32. Link to Article


Athippozhy A, Lehrberg J, Monaghan JR, Gardiner DM, Voss SR. 2014. Characterization of in vitro transcriptional responses of dorsal root ganglia cultured in the presence and absence of blastema cells from regenerating salamander limbs. Regeneration 1:1-10. PubMed


Page RB, Boley MA, Kump DK, Voss SR. 2013. Genomics of a metamorphic timing QTL: met1 maps to a unique genomic position and regulates morph and species-specific patterns of brain transcription. Genome Biology and Evolution 5:1716-1730. PubMed


Voss GJ, Kump DK, Walker JA, Voss SR. 2013. Variation in salamander tail regenerative outgrowth is associated with genetic factors that determine tail morphology. PLoS One 8:e67274. PubMed


Hui SP, Monaghan JR, Voss SR, Ghosh, S. 2013. Expression pattern of noga-a, mag, and ngr in regenerating urodele spinal cord. Developmental Dynamics 242:847-60. PubMed


Voss SR, Putta S, Walker JA, Smith JJ, Maki N, Tsonis P. 2013. Salamander Hox Clusters Contain Repetitive DNA and Expanded Non-Coding Regions: A Typical Hox Structure for Non-Mammalian Tetrapod Vertebrates? Human Genomics 7:9. PubMed


Johnson CK, Voss SR. 2013. Salamander Paedomorphosis: Linking thyroid hormone to salamander life history and life cycle evolution. Current Topics in Developmental Biology 103:229-258. PubMed


Tapia N, Reinhardt P, Duemmler A, Wu G, Araúzo-Bravo MJ, Esch D, Greber B, Cojocaru V, Rascon CA, Tazaki A, Kump K, Voss R, Tanaka EM, Schöler HR. 2012. Reprogramming to pluripotency is an ancient trait of vertebrate Oct4 and Pou2 proteins. Nature Communications 3:1279. PubMed


Voss SR, Kump KD, Walker JA, Shaffer HB, Voss GJ. 2012. Thyroid hormone responsive QTL and the evolution of paedomorphic salamanders. Heredity, 109:293-298. PubMed


Monaghan JR, Athippozhy A, Seifert AW,  Putta S, Stromberg AJ, Maden M, Gardiner DM, and Voss SR. 2012. Gene expression patterns specific to the regenerating limb of the Mexican axolotl. Biology Open 1:937-948.


Zhu W, Kuo D, Nathanson J, Satoh A, Pao GM, Yeo GW, Gene W. Yeo, Bryant SV, Voss SR, Gardiner DM, Hunter T. 2012. Retrotransposon LINE-1 is activated during salamander limb regeneration. Development, Growth, and Differentiation 54:673-685.


Zhu W, Pao GM, Satoh A, Cummings G, Monaghan JR, Harkins TT, Bryant SV, Voss SR, Gardiner DM, Hunter T. 2012. Activation of germline-specific genes is required for limb regeneration in the Mexican axolotl. Developmental Biology 370:42-51.


Seifert, A.W., Monaghan, J.R., Voss, S.R., and Maden, M. 2012. Skin regeneration in adult axolotls: a blueprint for scar-free healing in vertebrates. PLoS ONE 7:e32875.


Huggins P, Johnson C, Schoergendorfer A, Putta S, Stromberg A, and Voss SR. 2012. Identification of thyroid hormone responsive genes from the brain of the Mexican axolotl (Ambystoma mexicanum).  Comparative Biochemistry and Physiology Part C: Pharmacology and Toxicology 155:128-135.


Voss, S.R., Kump, K.D., Putta, S., Pauly, N., Reynolds, A., Henry, R.J., Basa, S., Walker, J.A., and Smith, J.J. 2011. Origin of avian and amphibian chromosomes by fusion, fission, and retention of ancestral chromosomes. Genome Research 8:1306-1312.


Cosden, R., Latterman, C., Romine, S., Voss, S.R., Gao, J., and MacLeod, J.N. 2011. Intrinsic repair of full-thickness articular cartilage defects in the axolotl salamander. Osteoarthritis and Cartilage 19:200-205.


Sharanowski BJ, Robbertse B, Walker J, Voss SR, Yoder R, Spatafora J, Sharkey MJ. 2010. Expressed sequence tags reveal Proctotrupomorpha (minus Chalcidoidea) as sister to Aculeata (Hymenoptera: Insecta). Molecular Phylogenetics and Evolution 57:101-12.


Dixon JE, Allegrucci C, Redwood C, Kump DC, Bian Y, Chatfield J, Chen Y-S, Sottile V, Voss SR, Alberio R, Johnson AD. 2010. Axolotl nanog expression in mouse embryonic stem cells demonstrates pluripotency is conserved from urodele amphibians to mammals. Development 137:2973-80.


Page RB, Boley M, Smith JJ, Voss SR. 2010. Microarray analysis of a salamander hopeful monster reveals transcriptional signatures of paedomorphic brain development. BMC Evolutionary Biology 10:199.


Fitzpatrick BM, Smith JJ, Voss SR, Shaffer HB. 2010. Rapid spread of invasive genes into a threatened native species. PNAS 107:3606-10.


Rao N, Jhamb D, Milner D, Li B, Song F, Wang M, Voss SR, Palakal M, King MW, Nye HLD, Cameron JA, Stocum DL. 2009. Proteomic analysis of blastema formation in regenerating axolotl limbs. BMC Biology 7:83.


LeVine H III, Ding Q, Walker JA, Voss SR, Augelli-Szafran CE. 2009.  Clioquinol and other hydroxyquinoline derivatives inhibit A_(1–42) oligomer assembly. Neuroscience Letters 465: 99–103.


Fitzpatrick BM, Shaffer HB, Johnson JJ, Kump K, Voss SR. 2009. Genome-wide SNP-typing shows rapid allele fixation in a tiger salamander hybrid zone. BMC Evolutionary Biology 9:176.


Page RB, Monaghan JR, Walker JA, Voss SR. 2009. An integrative model of transcriptional and morphological changes during TH-induced metamorphosis of the Mexican axolotl. General and Comparative Endocrinology 162:219-32.


Smith JJ, Voss SR. 2009. Amphibian sex determination: segregation and linkage analysis using members of the tiger salamander species complex (Ambystoma mexicanum and A. tigrinum). Heredity 102:542-548.


Monaghan JR, Epp L, Putta S, Page RB, Walker J, Zhu W, Pao GM, Verma IM, Hunter T, Bryant SV, Gardiner DM, Harkins TT, Voss SR. 2009. Microarray and DNA Sequence Analysis of Transcription During Nerve-Dependent Limb Regeneration. BMC Biology 7:1. 


Smith JJ, Putta S, Zhu W, Pao GM, Verma IM, Hunter T, Bryant SV, Gardiner DM, Harkins TT, Voss SR. 2009. Genic regions of a large salamander genome contain long introns and novel genes. BMC Genomics 10:19.


Page RB, Voss SR, Samuels AK, Smith JJ, Putta S, Beachy CK. 2008. Effect of thyroid hormone concentration on the transcriptional response underlying induced metamorphosis in the Mexican axolotl (Ambystoma). BMC Genomics 9:78.


Smith JJ, Voss SR. 2007. Chromosomal regions from bird and mammalian sex chromosomes were linked ancestrally. Genetics 177: 607-613.


Theodosiou M, Monaghan JR, Spencer ML, Voss SR, Noonan DJ. 2007. Isolation and characterization of axolotl NPDC-1 and its effects on retinoic acid receptor signaling. Comparative Biochemistry and Physiology Part B 147:260-270.


Putta S, Smith JJ, Voss SR. 2007. A new software tool for aligning transcript maps to sequenced genomes (MapToGenome): Identifying conserved chromosomal segments and evaluating genome assemblies. Evolutionary Bioinformatics Online 2:15-25.


Monaghan JR, Walker JA, Beachy CK, Voss SR. 2007. Microarray analysis of early gene expression during natural spinal cord regeneration in the salamander Ambystoma mexicanum. Journal of Neurochemistry 101:27-40.


Page RB, Monaghan JR, Samuels AK, Smith JJ, Beachy CK, Voss SR. 2007. Microarray analysis identifies keratin loci as sensitive biomarkers for thyroid hormone disruption in salamanders (Ambystoma). Comparative Biochemistry and Physiology Part C: Pharmacology and Toxicology, 145:15-27.


Smith JJ, Voss SR. 2006. Gene order data from a model amphibian: New perspectives on vertebrate genome structure and evolution. BMC Genomics 7:219.


Weisrock DW, Shaffer HB, Storz BL, Storz SR, Voss SR. 2006. The value of multiple nuclear gene sequences in phylogenetic analysis of species boundaries: a case study in the adaptive radiation of Mexican ambystomatid salamanders. Molecular Ecology 15:2489-2503.


Jones MT, Voss SR, Ptacek MB, Weisrock D, Tonkyn DW 2006. Population genetics and geographic variation in the shovel-nosed salamander, Desmognathus marmoratus. Molecular Phylogenetics and Evolution 38:280-287.


Smith, J.J., Putta, S., Walker, J.A., Kump, D.C., Samuels, A.K., Monaghan, J.R., Weisrock, D.W., Staben, C., and Voss, S.R. 2005. Sal-Site: Integrating new and existing ambystomatid research and information resources. BMC Genomics 6:181.


Smith, J.J., Kump, K., Walker, J.A., Parichy, D.M., and Voss, S.R. 2005. A genetic linkage map for tiger salamander and mexican axolotl (Ambystoma): Enabling gene mapping, comparative genomics, and PCR marker development in Ambystoma. Genetics 171:1161-1171.


Voss, S.R. and J.J. Smith. 2005. Evolution of salamander life cycles: A major effect QTL contributes to both continuous and discrete variation for metamorphic timing. Genetics 170:275-181.


Samuels, A.K., D. Weisrock, J.J. Smith, S. Putta, J. Walker, K. France, and S.R. Voss. 2005. Transcriptional and phylogenetic analysis of 5 complete ambystomatid salamander mitochondrial genomes. Gene 349:43-53.


Putta, S., J.J. Smith, J. Walker, M. Rondet , D. Weisrock, J. Monaghan, K. Kump, D.C. King, N. J. Maness, B. Habermann, E. Tanaka, S.V. Bryant, D.M. Gardiner, D.M. Parichy, and S.R. Voss. 2004. From Biomedicine to Natural History Research: Expressed Sequence Tag Resources for Ambystomatid Salamanders. BMC Genomics 5:54.


Shaffer, H.B. Fellers, G.M., Voss, S.R., Oliver J.C., and Pauly, G.B. 2004. Species boundaries, phylogeography, and conservation genetics of the red-legged frog (Rana aurora/draytonii) complex. Molecular Ecology 13:2667-2677.


Voss, S.R., K. Prudic, J. Oliver, and H.B. Shaffer. 2003. Candidate gene analysis of metamorphic timing in ambystomatid salamanders. Molecular Ecology 12:1217-1223.


Riley, S.P.D., H.B. Shaffer, S.R. Voss, and B.M. Fitzpatrick 2003. Hybridization between a rare, native tiger salamander (Ambystoma californiense) and its introduced congener. Ecological Applications13:1263-1275.


Voss, S.R., J.J. Smith, D.M. Gardiner, and D.M. Parichy. 2001. Conserved vertebrate chromosomal segments in the large salamander genome. Genetics 158:735-746.


Voss, S.R. and H.B. Shaffer. 2000. Evolutionary genetics of metamorphic failure using wild-caught versus laboratory axolotls (Ambystoma mexicanum). Molecular Ecology 9:1401-1408.


Voss, S.R., H.B. Shaffer, J. Taylor, R. Safi, and V. Laudet. 2000. Candidate gene analysis of thyroid hormone receptors in metamorphosing and non-metamorphosing salamanders. Heredity 85:107-114.


Shaffer, H.B., G.M. Fellers, A. Magee, and S.R. Voss.  2000. The genetics of amphibian declines: Population substructure and molecular differentiation in the Yosemite Toad, Bufo Canorus (Anura, Bufonidae) based on SSCP and mtDNA sequence data. Molecular Ecology 9:245-257.


Parichy, D.M., M. Stigson, and S.R. Voss. 1999. Genetic analysis of steel and the PG-M/Versican-encoding gene AxPG as candidates for the white (d) pigmentation mutant in the salamander Ambystoma mexicanum. Development, Genes, and Evolution 209:349-356.


Voss, S.R and H.B. Shaffer. 1997. Adaptive evolution via a major gene effect: paedomorphosis in the Mexican axolotl. Proceedings of the National Academy of Sciences 94: 14185-14189.


Voss, S.R. and H.B. Shaffer. 1996. What insights into the developmental traits of urodeles does the study of interspecific hybrids provide? International Journal of Developmental Biology 40:885-893.


Shaffer, H.B. and S.R. Voss. 1996. Phylogenetic and mechanistic analysis of a developmentally integrated character complex: alternate life history modes in ambystomatid salamanders. American Zoologist 36:24-35.


Voss, S.R., D.G. Smith, C.K. Beachy and D.G. Heckel 1995. Allozyme variation among geographically isolated populations of the salamander Leurognathus marmoratus. Journal of Herpetology 29:493-497.


Voss, S.R. 1995.  Genetic basis of paedomorphosis in the axolotl, Ambystoma mexicanum: a test of the single gene hypothesis. Journal of Heredity 86:441-447.


Voss, S.R. 1993. The relationship between stream order and length of larval period in the salamander Eurycea wilderae. Copeia 1993:736-742.


Voss, S.R. 1993. Effect of temperature on body size, developmental stage, and timing of hatching in Ambystoma maculatum. Journal of Herpetology 27:329-333.




Voss SR, Athippozhy AT, Woodcock MR. 2015. Transcriptomics Using Axolotls. In Salamanders in Regeneration Research: Methods and Protocols. Springer.


Baddar NW, Woodcock MR, Khatri S, Kump DK, Voss SR. 2015. Sal-Site: Research Resources for the Mexican Axolotl. In Salamanders in Regeneration Research: Methods and Protocols. Springer.


Seifert AW, Voss SR. 2013. Revisiting the relationship between regenerative ability and aging. BMC Biology 11:2 


Voss, S.R., Epperlein, H.H., Schroeder, B., and Tanaka, E.M. 2009. The axolotl. In Emerging Model Organisms. Cold Spring Harbor Press.  


Page, R.B., and Voss, S.R. 2009. Induction of Metamorphosis in Axolotls (Ambystoma mexicanum). Cold Spring Harbor Protocols.


Theodosiou, M., J.R. Monaghan, S.R. Voss, and D. Noonan. 2005. Impact of NPDC on thyroid receptor signaling FASEB JOURNAL 19 (4): A299.


Voss, S.R. and D.M. Parichy. 2001. Salamander Genome Project. Axolotl Newsletter 29.


Stigson, M., Parichy, D.M. & Voss, S.R. 1999. Genetic analysis of PG-M / versican and Steel factor as candidates for the white (d) gene in the axolotl, Ambystoma mexicanum. In: Regulatory Processes in Development: The Legacy of Sven Hˆrstadius (Olsson, L. & Jacobson, C.-O., Eds.). Wenner-Gren International, Portland Press, London.


Voss, S.R., J.J. Smith, and D.M. Parichy. 1999. Towards a genomics resource for evolutionary and developmental studies of ambystomatid salamanders. American Zoologist 39:11A.


Mason K. A., Parker N. B., Parichy D. M. and Voss S. R. Molecular characterization of c- kit from the Mexican axolotl. Pigment Cell Res. 11, 175A (1998)


Voss, S.R. and H.B. Shaffer. 1998. Evolutionary genetics of metamorphic failure in the mexican axolotl. American Zoologist 38:197A.


Voss, S.R. and M. Stigson. 1996. Genetic linkage analysis and mapping of the gene encoding a PG-M/Versican-like proteoglycan core protein in relation to the white (d) locus in the mexican axolotl, Ambystoma mexicanum. In Large Chondroitin Sulfate Proteoglycans in the Axolotl Embryo, M. Stigson, Ch. V, Pp. 1-9. Acta Universitais Upsaliensis, Uppsala.


Voss, S.R. 1993. Randomly amplified polymorphic DNA (RAPD) analysis of ambystomatid salamanders. Axolotl Newsletter 22:28-32.


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